Characterize induced proximity from recruitment to proteome response
Opsin connects compound, target and E3 identity with ternary-complex evidence, degradation kinetics, quantitative proteomics, exposure and phenotype data.
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Binary affinity, cooperativity and interface compatibility assessed against structural evidence, so complex formation is established as the basis for any degradation that follows.
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Mechanism map
The evidence supporting each step, from recruitment through ubiquitination to phenotype.
Causal graph
Links target and neosubstrate degradation to pathway, tissue and safety outcomes.
Cross-species assessment
Compares molecular compatibility, expression, degradation and exposure across species.
Compound comparison
Degradation, selectivity, exposure margin, translational coverage and evidence completeness across a series.
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Ranked by causal uncertainty, cross-species relevance, decision impact, material and turnaround time.
A worked example of degrader prioritisation against a single target, and the selectivity constraint that determined the ranking.
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