Prioritize peptides on stability, exposure and engagement
Opsin relates peptide chemistry, target biology and measured exposure to the stability and developability constraints on a peptide series.
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Parent disappearance and metabolite formation resolved per matrix, so each half-life carries the matrix it was measured in and the cleavage sites implied.
Available in Octopus
Candidate view
Potency, stability, exposure and developability per candidate, with evidence coverage and progression status.
Causal interpretation
Traces a sequence or modification through the property it changes to the exposure, engagement and biological consequence that follow.
Cross-species assessment
Compares target conservation, matrix-specific stability, metabolism, PK and tissue relevance, and states the translation gaps.
Evidence view
Marks each value as measured, predicted, derived, literature-supported, missing or outside the model domain.
Study plan
Ranked assays with species, matrix, concentration, time points, controls, analytical readouts and decision criteria.
A worked example of peptide prioritisation against a single target, and the proteolytic constraint that determined the ranking.
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