Prioritize compounds on exposure, developability and safety
Opsin relates molecular structure, target biology and measured exposure to the developability and safety constraints on a chemical series.
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Solubility, permeability, metabolic stability, protein binding and transport compared across the series, locating constraints at the scaffold and at the substituent.
Available in Octopus
Series view
Potency, ADME, pan-organ safety and exposure margins across the series, with evidence coverage and progression status.
Causal interpretation
Traces a predicted signal through mechanism and tissue response to the organ-level consequence and the programme risk it carries.
Cross-species assessment
Compares target biology, tissue relevance, metabolism and exposure to give translational coverage across species.
Safety attribution
Assigns a finding to target-mediated, off-target, metabolite-mediated or exposure-driven cause, and flags what is species or assay dependent.
Evidence view
Marks each value as measured, predicted, derived, literature-supported, missing or outside the model domain.
Study plan
Ranked assays with species, biological system, exposure range, controls, readouts and decision criteria.
A worked example of small-molecule prioritisation against a single target, and the developability constraint that determined the ranking.
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